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The Role of B Cells in Transplantation Rejection
J Korean Soc Transplant 2018;32:1-6
Published online March 31, 2018
© 2018 The Korean Society for Transplantation.

Tae Jin Kim, M.D.1,2

Division of Immunobiology, Sungkyunkwan University School of Medicine1, Suwon,
Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University2, Seoul, Korea
Correspondence to: Tae Jin Kim
Division of Immunobiology, Sungkyunkwan University School of Medicine, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Korea
Tel: 82-31-299-6161, Fax: 82-31-299-6179
E-mail: tjkim@skku.edu
Received March 4, 2018; Accepted March 7, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
B cells play a role in graft rejection via several mechanisms. Specifically, B cells produce high-affinity antibodies to alloantigens including allogeneic major histocompatibility complex (MHC) with the help of follicular helper T cells. B cells also function as antigen-presenting cells for alloreactive T cells, resulting in the activation of alloreactive T cells. Conversely, the frequency of regulatory B cells increases under inflammatory conditions and suppresses the rejection process. Here, the differential roles of the major B cell subpopulations (B-1, follicular B, marginal zone B, and regulatory B cells) involved in transplantation rejection are discussed together with their interaction with T cells.
Keywords : B cell, Transplant rejection, Antibody diversity, Helper T cell, B-1 cell


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